Il4i1^H46-b
Allele Detail

Summary

• Symbol: Il4i1^H46-b
• Name: interleukin 4 induced 1; histocompatibility 46, b variant
• MGI ID: MGI:6197069
• Synonyms: H46^b
• Gene: Il4i1 Location: Chr7:44485712-44490233 bp, + strand Genetic Position: Chr7, 28.93 cM
• Alliance: Il4i1^H46-b page

Mutation origin

• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Not Applicable (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: This minor histocompatibility antigen, initially identified as being between C57BL/10ScSn and 129/Rr but also found to be between C57BL/6J and 129P3/J, is caused by a single amino acid change at residue 25, which is alanine in C57BL/6J-derived H46-a and methionine for 129-derived H46-b. The 2 nucleotide sequence variations underlying this are G73A and C74T and the core antigenic peptide from each compete similarly for binding A^b. The core antigenic peptide in H46-b is HMFVEAIPELQ. (J:264442)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il4i1 Mutation: 105 strains or lines available

References

• Original: J:10078 Roopenian DC, et al., Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics. 1989;30(5):335-43
• All: 2 reference(s)