Ankrd16^tm1.1Slac
Targeted Allele Detail

Summary

• Symbol: Ankrd16^tm1.1Slac
• Name: ankyrin repeat domain 16; targeted mutation 1.1, Susan L Ackerman
• MGI ID: MGI:6197500
• Gene: Ankrd16 Location: Chr2:11782687-11795140 bp, + strand Genetic Position: Chr2, 9.05 cM
• Alliance: Ankrd16^tm1.1Slac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262421
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of eoxn 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the selection cassette. (J:262421)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ankrd16 Mutation: 25 strains or lines available

References

• Original: J:262421 Vo MN, et al., ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Nature. 2018 May;557(7706):510-515
• All: 1 reference(s)