Clock^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Clock^m1Btlr
• Name: clock circadian regulator; mutation 1, Bruce Beutler
• MGI ID: MGI:6197763
• Synonyms: uhr
• Gene: Clock Location: Chr5:76357715-76452639 bp, - strand Genetic Position: Chr5, 40.63 cM
• Alliance: Clock^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 76,229,554 (v38) on chromosome 5, or base pair 75,447 in the GenBank genomic region NC_000071 encoding Clock. The mutation corresponds to residue 2,285 in the NM_007715 mRNA sequence in exon 21 of 23 total exons, residue 2,242 in the NM_001289826 mRNA sequence in exon 21 of 23 total exons, and residue 2,101 in the NM_001305222 mRNA sequence in exon 21 of 23 total exons. The mutation results in substitution of glutamine 633 to a premature stop codon (Q633*) in the CLOCK protein. (J:264640)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clock Mutation: 104 strains or lines available

References

• Original: J:264640 Turer E, et al., Mutagenetix entry for uhr. MGI Direct Data Submission. 2018
• All: 1 reference(s)