Gck^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Gck^m2Btlr
• Name: glucokinase; mutation 2, Bruce Beutler
• MGI ID: MGI:6197913
• Synonyms: tootsie
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 5,909,150 (v38) on chromosome 11, or base pair 40,932 in the GenBank genomic region NC_000077 encoding Gck. The mutation corresponds to residue 898 in the mRNA sequence NM_010292.5 (c.898T>A) within exon 4 of 10 total exons. The mutation results in a methionine to lysine substitution at amino acid 139 (p.M139K) in the GCK protein. (J:264650)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 63 strains or lines available

References

• Original: J:264650 Turer E, et al., Mutagenetix entry for tootsie. MGI Direct Data Submission. 2018
• All: 1 reference(s)