Prkdc^m12Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkdc^m12Btlr
• Name: protein kinase, DNA activated, catalytic polypeptide; mutation 12, Bruce Beutler
• MGI ID: MGI:6198357
• Synonyms: liming
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^m12Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to A transversion at base pair 15,752,829 (v38) on chromosome 16, or base pair 115,387 in the GenBank genomic region NC_000082. The mutation corresponds to residue 6,998 in the mRNA sequence NM_011159 within exon 52 of 86 total exons.The mutation results in substitution of tyrosine 2,325 for a premature stop codon (Y2325*) in the DNA-PKCS protein. (J:264708)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 417 strains or lines available

References

• Original: J:264708 Choi JH, et al., Mutagenetix entry for liming. MGI Direct Data Submission. 2018
• All: 1 reference(s)