Slc25a3^tm1.1Jmol
Targeted Allele Detail

Summary

• Symbol: Slc25a3^tm1.1Jmol
• Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3; targeted mutation 1.1, Jeffery Molkentin
• MGI ID: MGI:6198542
• Synonyms: Slc25a3^fl
• Gene: Slc25a3 Location: Chr10:90952436-90959902 bp, - strand Genetic Position: Chr10, 45.6 cM
• Alliance: Slc25a3^tm1.1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229795
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct contains loxP sites flanking exons 1 and 2. An FRT-flanked neomycin cassette is present in the construct, however, Flp-mediated recombination removed the cassette. (J:229795)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc25a3 Mutation: 24 strains or lines available

References

• Original: J:229795 Kwong JQ, et al., Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy. Cell Death Differ. 2014 Aug;21(8):1209-17
• All: 2 reference(s)