Ggcx^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Ggcx^tm1.1Kry
• Name: gamma-glutamyl carboxylase; targeted mutation 1.1, Gerard Karsenty
• MGI ID: MGI:6198558
• Synonyms: Ggcx^fl
• Gene: Ggcx Location: Chr6:72391291-72407695 bp, + strand Genetic Position: Chr6, 32.27 cM, cytoband C3
• Alliance: Ggcx^tm1.1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264734
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exons 1 and 2 floxed. (J:264734)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggcx Mutation: 37 strains or lines available

References

• Original: J:264734 Ferron M, et al., GGCX and VKORC1 inhibit osteocalcin endocrine functions. J Cell Biol. 2015 Mar 16;208(6):761-76
• All: 3 reference(s)