Vkorc1^tm1.2Kry
Targeted Allele Detail

Summary

• Symbol: Vkorc1^tm1.2Kry
• Name: vitamin K epoxide reductase complex, subunit 1; targeted mutation 1.2, Gerard Karsenty
• MGI ID: MGI:6198562
• Gene: Vkorc1 Location: Chr7:127492235-127494789 bp, - strand Genetic Position: Chr7, 69.81 cM
• Alliance: Vkorc1^tm1.2Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264734
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette, exon 2 and exon 3. (J:264734)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vkorc1 Mutation: 7 strains or lines available

References

• Original: J:264734 Ferron M, et al., GGCX and VKORC1 inhibit osteocalcin endocrine functions. J Cell Biol. 2015 Mar 16;208(6):761-76
• All: 3 reference(s)