Kctd19^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kctd19^em1(IMPC)J
• Name: potassium channel tetramerisation domain containing 19; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6198567
• Gene: Kctd19 Location: Chr8:106109439-106140134 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Kctd19^em1(IMPC)J page
• IMPC: Kctd19 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GATGACATCATATCACCTAA and GGACGGTATTTTAAAATAAA, which resulted in a 559 bp deletion beginning at Chromosome 8 position 105,396,104 bp and ending after 105,396,662 bp (GRCm38/mm10). This mutation deletes (ENSMUSE00000342753) (exon 3) and 408 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 100 and early truncation 37 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kctd19 Mutation: 52 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)