Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Transgene Detail
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Symbol: |
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc |
Name: |
transgene insertion 1, David C Chan |
MGI ID: |
MGI:6198713 |
Synonyms: |
Mfn2T105M, Tg1Mfn2T105M |
Transgene: |
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc Location: unknown Genetic Position: Chr11, Syntenic
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Alliance: |
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc expresses
1 gene
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Mutation details: The Mnx1 (homeobox HB9) promoter drives the expression of a C-terminally Myc-tagged mouse mitofusin 2 with the T105M mutation found in families with Charcot-Marie-Tooth disease type 2A followed by an IRES and an EGFP in motor neurons. Western blot analysis with an anti-Myc antibody confirmed expression of the transgene. Sequence analysis of the insertion site indicates that the transgene inserted into a non-coding region on chromosome 11 between genes Rad51c and Ppm1e.
(J:132035)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:132035 Detmer SA, et al., Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet. 2008 Feb 1;17(3):367-75 |
All: |
1 reference(s) |
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