Mettl16^em2Rspi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl16^em2Rspi
• Name: methyltransferase 16, N6-methyladenosine; endonuclease-mediated mutation 2, Ramesh S Pillai
• MGI ID: MGI:6199132
• Synonyms: line #2175, Mettl16^em2Embrp
• Gene: Mettl16 Location: Chr11:74661658-74716649 bp, + strand Genetic Position: Chr11, 45.76 cM, cytoband B4
• Alliance: Mettl16^em2Rspi page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 7 bp leading to the removal of the splice donor site in intron 4. (J:265047)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl16 Mutation: 68 strains or lines available

References

• Original: J:265047 Mendel M, et al., Methylation of Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development. Mol Cell. 2018 Sep 5
• All: 1 reference(s)