Fgfr4^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Fgfr4^M1Btlr
• Name: fibroblast growth factor receptor 4; mutation 1, Bruce Beutler
• MGI ID: MGI:6199491
• Synonyms: Modest
• Gene: Fgfr4 Location: Chr13:55300631-55316572 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Fgfr4^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Undefined
• Mutation details: ENU-induced G to A transversion at base pair 55,166,251 (v38) on chromosome 13, or base pair 13,434 in the GenBank genomic region NC_000079 encoding Fgfr4. The mutation corresponds to residue 1,939 in the mRNA sequence NM_008011 within exon 13 of 18 total exons. The mutation results in a valine (V) to methionine (M) substitution at position 593 (V593M) in the FGFR4 protein. (J:265097)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr4 Mutation: 42 strains or lines available

References

• Original: J:265097 Turer E, et al., Mutagenetix entry for Modest. MGI Direct Data Submission. 2018
• All: 1 reference(s)