Mpz^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mpz^m1Btlr
• Name: myelin protein zero; mutation 1, Bruce Beutler
• MGI ID: MGI:6199507
• Synonyms: taz
• Gene: Mpz Location: Chr1:170978282-170988699 bp, + strand Genetic Position: Chr1, 79.05 cM
• Alliance: Mpz^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 171,158,810 (v38) on chromosome 1, or base pair 8,098 in the GenBank genomic region NC_000067 encoding Mpz. The mutation corresponds to residue 458 in the NM_008623 mRNA sequence in exon 5 of 8 total exons. The mutation results in an arginine (R) to cysteine (C) substitution at position 98 (R98C) in both variants of the MPZ protein. (J:265100)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpz Mutation: 28 strains or lines available

References

• Original: J:265100 Prince L, et al., Mutagenetix entry for taz. MGI Direct Data Submission. 2018
• All: 1 reference(s)