Plcg2^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Plcg2^M3Btlr
• Name: phospholipase C, gamma 2; mutation 3, Bruce Beutler
• MGI ID: MGI:6199511
• Synonyms: Poseidon2
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 117,577,874 (v38) on chromosome 8, or base pair 79,600 in the GenBank genomic region NC_000074 encoding Plcg2. The mutation corresponds to residue 1,018 in the mRNA sequence NM_172285 within exon 10 of 33 total exons. The mutation results in an isoleucine to phenylalanine substitution at position 273 (I273F) in the phospholipase C gamma 2 (PLC-2) protein. (J:265101)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:265101 Choi JH, et al., Mutagenetix entry for Poseidon2. MGI Direct Data Submission. 2018
• All: 1 reference(s)