Slc5a2^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Slc5a2^m2Btlr
• Name: solute carrier family 5 (sodium/glucose cotransporter), member 2; mutation 2, Bruce Beutler
• MGI ID: MGI:6199601
• Synonyms: dregs
• Gene: Slc5a2 Location: Chr7:127864855-127871602 bp, + strand Genetic Position: Chr7, 70.08 cM, cytoband F4
• Alliance: Slc5a2^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 128,267,505 (v38) on chromosome 7, or base pair 1,809 in the GenBank genomic region NC_000073 within the donor splice site of intron 4. The effect of the mutation at the cDNA and protein levels has not been examined. The mutation may result in skipping of the 165-base pair exon 4, which would result in an in-frame deletion of amino acids 100 to 154 in the SGLT2 protein, which is normally 670 amino acids long. (J:265117)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc5a2 Mutation: 35 strains or lines available

References

• Original: J:265117 Sun L, et al., Mutagenetix entry for dregs. MGI Direct Data Submission. 2018
• All: 1 reference(s)