Itgb2^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itgb2^m2Btlr
• Name: integrin beta 2; mutation 2, Bruce Beutler
• MGI ID: MGI:6199651
• Synonyms: newhome
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 77,559,681 (v38) on chromosome 10, or base pair 29,354 in the GenBank genomic region NC_000076. The mutation corresponds to residue 1,730 in the mRNA sequence NM_008404 within exon 12 of 16 total exons. The mutation results in a valine (V) to isoleucine (I) substitution at position 539 (V539I) in the integrin 2 protein. (J:265125)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 50 strains or lines available

References

• Original: J:265125 Dao D, et al., Mutagenetix entry for newhome. MGI Direct Data Submission. 2018
• All: 1 reference(s)