Itgb2m3Btlr
Chemically induced Allele Detail
|
Symbol: |
Itgb2m3Btlr |
Name: |
integrin beta 2; mutation 3, Bruce Beutler |
MGI ID: |
MGI:6199655 |
Synonyms: |
nibbler |
Gene: |
Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
|
Alliance: |
Itgb2m3Btlr page
|
|
Strain of Origin: |
C57BL/6J
|
Project Collection: |
Beutler Mutagenetix
|
|
Allele Type: |
|
Chemically induced (ENU) (Not Specified) |
Mutation: |
|
Single point mutation
|
|
|
Mutation details: ENU-induced G to A transition at base pair 77,561,216 (v38) on chromosome 10, or base pair 30,888 in the GenBank genomic region NC_000076 within the donor splice site of intron 14. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in the use of a cryptic site in intron 14, resulting in an 80-base pair insertion of intron 14. This predicts a frame shifted protein product beginning after amino acid 694 of the protein, which is normally 770 amino acids in length, and terminating after the inclusion of 9 aberrant amino acids.
(J:265126)
|
Inheritance: |
|
Recessive |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Itgb2 Mutation: |
50 strains or lines available
|
|
Original: |
J:265126 Nair-Gill E, et al., Mutagenetix entry for nibbler. MGI Direct Data Submission. 2018; |
All: |
1 reference(s) |
|