Vav1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Vav1^m1Btlr
• Name: vav 1 oncogene; mutation 1, Bruce Beutler
• MGI ID: MGI:6199670
• Synonyms: tardive
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 57,303,079 (v38) on chromosome 17, or base pair 24,001 in the GenBank genomic region NC_000083. The mutation corresponds to residue 1,428 in the mRNA sequence NM_011691 within exon 14 of 27 total exons. The mutation results in substitution of lysine 444 for a premature stop codon (K444*) in the VAV1 protein. (J:265128)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 60 strains or lines available

References

• Original: J:265128 Zhong X, et al., Mutagenetix entry for tardive. MGI Direct Data Submission. 2018
• All: 1 reference(s)