Vav1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Vav1^m2Btlr
• Name: vav 1 oncogene; mutation 2, Bruce Beutler
• MGI ID: MGI:6199674
• Synonyms: plain_sight
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 57,297,122 (v38) on chromosome 17, or base pair 18,044 in the GenBank genomic region NC_000083. The mutation corresponds to residue 621 in the mRNA sequence NM_011691 within exon 5 of 27 total exons. The mutation results in a glutamic acid to lysine substitution at amino acid 175 (E175K) in the VAV1 protein. (J:265130)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 60 strains or lines available

References

• Original: J:265130 Zhong X, et al., Mutagenetix entry for plain_sight. MGI Direct Data Submission. 2018
• All: 1 reference(s)