Ebf1^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ebf1^M3Btlr
• Name: early B cell factor 1; mutation 3, Bruce Beutler
• MGI ID: MGI:6199994
• Synonyms: Oregano2
• Gene: Ebf1 Location: Chr11:44508144-44898918 bp, + strand Genetic Position: Chr11, 26.45 cM
• Alliance: Ebf1^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 44,990,504 (v38) on chromosome 11, or base pair 372,405 in the GenBank genomic region NC_000077 within intron 11 (12 base pairs from exon 12. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in the use of a cryptic site in intron 11, resulting in a 31-base pair insertion of intron 11. The insertion would cause a frame-shifted protein product beginning after amino acid 376 of the protein and premature termination after the inclusion of 14 aberrant amino acids. (J:265160)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebf1 Mutation: 74 strains or lines available

References

• Original: J:265160 Choi JH, et al., Mutagenetix entry for Oregano2. MGI Direct Data Submission. 2018
• All: 1 reference(s)