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Trpa1m1Btlr
Chemically induced Allele Detail
Summary
Symbol: Trpa1m1Btlr
Name: transient receptor potential cation channel, subfamily A, member 1; mutation 1, Bruce Beutler
MGI ID: MGI:6199997
Gene: Trpa1  Location: Chr1:14942872-14989086 bp, - strand  Genetic Position: Chr1, 4.5 cM
Alliance: Trpa1m1Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU-induced T to C transition at base pair 14,891,303 (v38) on chromosome 1, or base pair 27,712 in the GenBank genomic region NC_000067 within the donor splice site of intron 15. The mutation is predicted to result in skipping of the 94-nucleotide exon 15 (out of 27 total exons), resulting in a frame-shifted protein product beginning after amino acid 605, and termination after the inclusion of two aberrant amino acids. (J:262266)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpa1 Mutation:  94 strains or lines available
References
Original:  J:262266 Wang Y, et al., Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun. 2018 May 23;9(1):2041
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory