Klhl6m1Btlr
Chemically induced Allele Detail
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Symbol: |
Klhl6m1Btlr |
Name: |
kelch-like 6; mutation 1, Bruce Beutler |
MGI ID: |
MGI:6200013 |
Synonyms: |
cerulean |
Gene: |
Klhl6 Location: Chr16:19765242-19801766 bp, - strand Genetic Position: Chr16, 12.32 cM
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Alliance: |
Klhl6m1Btlr page
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Strain of Origin: |
C57BL/6J
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Project Collection: |
Beutler Mutagenetix
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Allele Type: |
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Chemically induced (ENU) (Not Specified) |
Mutation: |
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Single point mutation
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Mutation details: ENU-induced C to T transition at base pair 19,957,218 (v38) on chromosome 16, or base pair 25,832 in the GenBank genomic region NC_000082 encoding Klhl6. The mutation corresponds to residue 635 in the mRNA sequence NM_183390 within exon 3 of 7 total exons. The mutation results in substitution of glutamine 197 for a premature stop codon (Q197*) in the KLHL6 protein.
(J:265167)
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Inheritance: |
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Recessive |
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | | |
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Phenotypes: |
Affected Systems |
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hematopoietic system
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√
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increased B-1b cell number
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√
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decreased B cell number
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√
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decreased central memory CD4-positive, alpha-beta T cell number
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√
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increased T cell number
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√
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increased CD4-positive, alpha-beta T cell number
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√
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increased single-positive T cell number
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√
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immune system
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√
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increased B-1b cell number
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√
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decreased B cell number
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√
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decreased central memory CD4-positive, alpha-beta T cell number
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√
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increased T cell number
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√
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increased CD4-positive, alpha-beta T cell number
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√
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increased single-positive T cell number
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Klhl6 Mutation: |
48 strains or lines available
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Original: |
J:265167 Choi JH, et al., Mutagenetix entry for cerulean. MGI Direct Data Submission. 2018; |
All: |
1 reference(s) |
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