Ttc21b^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ttc21b^m1Btlr
• Name: tetratricopeptide repeat domain 21B; mutation 1, Bruce Beutler
• MGI ID: MGI:6200040
• Synonyms: plus-sized
• Gene: Ttc21b Location: Chr2:66014671-66086961 bp, - strand Genetic Position: Chr2, 39.08 cM
• Alliance: Ttc21b^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 66,242,679 (v38) on chromosome 2, or base pair 13,968 in the GenBank genomic region NC_000068 encoding Ttc21b. The mutation corresponds to residue 745 in the mRNA sequence NM_001047604 within exon 6 of 29 total exons. he mutation results in a leucine (L) to serine (S) substitution at position 221 (L221S) in the TTC21B protein. (J:265171)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttc21b Mutation: 52 strains or lines available

References

• Original: J:265171 Zhang Z, et al., Mutagenetix entry for plus-sized. MGI Direct Data Submission. 2018
• All: 1 reference(s)