Dicer1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dicer1^m1Btlr
• Name: dicer 1, ribonuclease type III; mutation 1, Bruce Beutler
• MGI ID: MGI:6200045
• Synonyms: everest
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 104,705,128 (v38) on chromosome 12, or base pair 47,197 in the GenBank genomic region NC_000078. The mutation corresponds to residue 3,161 in the mRNA sequence NM_148948 within exon 18 of 27 total exons. The mutation results in a tyrosine to phenylalanine substitution at position 961 (Y961F) in the DICER1 protein. (J:265172)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:265172 Choi JH, et al., Mutagenetix entry for everest. MGI Direct Data Submission. 2018
• All: 1 reference(s)