Nlrp1a^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp1a^m1Btlr
• Name: NLR family, pyrin domain containing 1A; mutation 1, Bruce Beutler
• MGI ID: MGI:6200049
• Synonyms: watermelon
• Gene: Nlrp1a Location: Chr11:70983062-71035530 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Nlrp1a^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 71,122,705 (v38) on chromosome 11, or base pair 22,269 in the GenBank genomic region NC_000077 encoding Nlrp1a. The mutation corresponds to residue 1,936 in the mRNA sequence NM_001004142 within exon 3 of 14 total exons. The mutation results in an aspartic acid to glycine substitution at amino acid 573 (D573G) in the NLRP1A protein. (J:265173)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp1a Mutation: 64 strains or lines available

References

• Original: J:265173 Choi JH, et al., Mutagenetix entry for watermelon. MGI Direct Data Submission. 2018
• All: 1 reference(s)