Nlrp1a^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp1a^m2Btlr
• Name: NLR family, pyrin domain containing 1A; mutation2, Bruce Beutler
• MGI ID: MGI:6200053
• Synonyms: dreary
• Gene: Nlrp1a Location: Chr11:70983062-71035530 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Nlrp1a^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 71,113,640 (v38) on chromosome 11, or base pair 31,334 in the GenBank genomic region NC_000077 within the acceptor splice site of intron 4. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation may result in skipping of the 171-base pair exon 5 (out of 14 total exons). Exon 5 encodes amino acids 669 to 725. (J:265174)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp1a Mutation: 64 strains or lines available

References

• Original: J:265174 Choi JH, et al., Mutagenetix entry for dreary. MGI Direct Data Submission. 2018
• All: 1 reference(s)