Serpina3c^tm1.1Chao
Targeted Allele Detail

Summary

• Symbol: Serpina3c^tm1.1Chao
• Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C; targeted mutation 1.1, Julie Chao
• MGI ID: MGI:6200073
• Synonyms: KS^fl
• Gene: Serpina3c Location: Chr12:104113166-104120187 bp, - strand Genetic Position: Chr12, 53.46 cM, cytoband F1
• Alliance: Serpina3c^tm1.1Chao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to have a loxP site upstream of exon 3, and an FRT-flanked neo cassette followed by a loxP site just downstream of exon 3 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 3 floxed. (J:265184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpina3c Mutation: 32 strains or lines available

References

• Original: J:265184 Guo Y, et al., Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway. J Cell Mol Med. 2018 Sep;22(9):4387-4398
• All: 1 reference(s)