Ptprc^M6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^M6Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 6, Bruce Beutler
• MGI ID: MGI:6200077
• Synonyms: Dumpling
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^M6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to G transversion at base pair 138,067,890 (v38) on chromosome 1, or base pair 107,867 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 3,508 in the mRNA sequence NM_001111316 within exon 31 of 33 total exons. The mutation results in a cysteine to glycine substitution at position 1,157 (C1157G) in variant 1 of the CD45 protein. (J:265186)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

References

• Original: J:265186 Choi JH, et al., Mutagenetix entry for Dumpling. MGI Direct Data Submission. 2018
• All: 1 reference(s)