Tg^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tg^m3Btlr
• Name: thyroglobulin; mutation 3, Bruce Beutler
• MGI ID: MGI:6200223
• Synonyms: ito4
• Gene: Tg Location: Chr15:66542606-66722570 bp, + strand Genetic Position: Chr15, 29.3 cM, cytoband D3-E
• Alliance: Tg^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T-to-A mutation at base pair 66,696,520 (GRCm38) on chromosome 15, or base pair 25,767 in the GenBank genomic region NC_000081 encoding Tg. The mutation corresponds to residue 4,077 in the NM_009375 mRNA sequence in exon 19 of 48 total exons. The mutation results in an isoleucine to lysine substitution of position 1,352 (p.I1352K) in the encoded peptide. (J:265197)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tg Mutation: 147 strains or lines available

References

• Original: J:265197 Turer E, et al., Mutagenetix entry for ito4. MGI Direct Data Submission. 2018
• All: 2 reference(s)