Mlh1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mlh1^m1Btlr
• Name: mutL homolog 1; mutation 1, Bruce Beutler
• MGI ID: MGI:6200234
• Synonyms: andalusia
• Gene: Mlh1 Location: Chr9:111057296-111100854 bp, - strand Genetic Position: Chr9, 60.92 cM
• Alliance: Mlh1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 111,271,410 (v38) on chromosome 9, or base pair 377 in the GenBank genomic region NC_000075 encoding Mlh1. The mutation corresponds to residue 199 in the mRNA sequence NM_026810 within exon 1 of 19 total exons. The mutation results in a cysteine to arginine substitution at position 39 (C39R) in the MLH1 protein. (J:265206)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlh1 Mutation: 44 strains or lines available

References

• Original: J:265206 Choi JH, et al., Mutagenetix entry for andalusia. MGI Direct Data Submission. 2018
• All: 1 reference(s)