Klf5^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Klf5^M1Btlr
• Name: Kruppel-like transcription factor 5; mutation 1, Bruce Beutler
• MGI ID: MGI:6200268
• Synonyms: Bernie
• Gene: Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
• Alliance: Klf5^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 99,302,230 (v38) on chromosome 14, or base pair 3,540 in the GenBank genomic region NC_000080 encoding Klf5. The mutation corresponds to residue 1,382 in the mRNA sequence NM_009769 within exon 2 of 4 total exons. The mutation results in an arginine (R) to cysteine (C) substitution at position 360 (R360C) in the KLF5 protein. (J:265229)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf5 Mutation: 37 strains or lines available

References

• Original: J:265229 Turer E, et al., Mutagenetix entry for Bernie. MGI Direct Data Submission. 2018
• All: 1 reference(s)