Stat2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Stat2^m1Btlr
• Name: signal transducer and activator of transcription 2; mutation 1, Bruce Beutler
• MGI ID: MGI:6200395
• Synonyms: numb
• Gene: Stat2 Location: Chr10:128106428-128128718 bp, + strand Genetic Position: Chr10, 76.5 cM
• Alliance: Stat2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 128,281,065 (v38) on chromosome 10, or base pair 10,507 in the GenBank genomic region NC_000076 within intron 8 (17 base pairs from exon 9). The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in usage of a cryptic site in intron 8. The resulting transcript would have a 15-base pair insertion of intron 8, and would cause a predicted in-frame insertion of five aberrant amino acids after amino acid 261 of the protein. (J:265265)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat2 Mutation: 39 strains or lines available

References

• Original: J:265265 Zhong X, et al., Mutagenetix entry for numb. MGI Direct Data Submission. 2018
• All: 1 reference(s)