Spatc1l^em1Choc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Spatc1l^em1Choc
• Name: spermatogenesis and centriole associated 1 like; endonuclease-mediated mutation 1, Chunghee Cho
• MGI ID: MGI:6200789
• Gene: Spatc1l Location: Chr10:76398106-76406035 bp, + strand Genetic Position: Chr10, 39.2 cM
• Alliance: Spatc1l^em1Choc page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated recombination created a 178 bp deletion in exon 1 spanning the ATG start site. PCR and immunoblot analysis confirmed the absence of RNA and protein expression in testes from homozygous mice. (J:265193)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spatc1l Mutation: 17 strains or lines available

References

• Original: J:265193 Kim J, et al., SPATC1L maintains the integrity of the sperm head-tail junction. EMBO Rep. 2018 Sep;19(9)
• All: 1 reference(s)