Cdk10^tm1.2Kald
Targeted Allele Detail

Summary

• Symbol: Cdk10^tm1.2Kald
• Name: cyclin dependent kinase 10; targeted mutation 1.2, Philipp Kaldis
• MGI ID: MGI:6201331
• Synonyms: Cdk10^null
• Gene: Cdk10 Location: Chr8:123951581-123958989 bp, + strand Genetic Position: Chr8, 72.09 cM
• Alliance: Cdk10^tm1.2Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262333
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 8. (J:262333)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk10 Mutation: 12 strains or lines available

References

• Original: J:262333 Windpassinger C, et al., CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. Am J Hum Genet. 2017 Sep 7;101(3):391-403
• All: 1 reference(s)