Zbed6^tm1.2Sson
Targeted Allele Detail

Summary

• Symbol: Zbed6^tm1.2Sson
• Name: zinc finger, BED type containing 6; targeted mutation 1.2, Leif Andersson
• MGI ID: MGI:6201365
• Gene: Zbed6 Location: Chr1:133547678-133589056 bp, - strand Genetic Position: Chr1, Syntenic
• Alliance: Zbed6^tm1.2Sson page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265506
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Recombinase mediated recombination removed the neo cassette and the entire coding region. (J:265506)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zbed6 Mutation: 26 strains or lines available

References

• Original: J:265506 Younis S, et al., The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2048-E2057
• All: 1 reference(s)