Rr143^tm1.1Sson
Targeted Allele Detail

Summary

• Symbol: Rr143^tm1.1Sson
• Name: regulatory region 143; targeted mutation 1.1, Leif Andersson
• MGI ID: MGI:6201366
• Synonyms: Igf2^A, Igf2^tm1.1Sson
• Gene: Rr143 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr143^tm1.1Sson page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265506
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Modified regulatory region)
• Mutations: Insertion, Single point mutation
• Mutation details: A single G-to-A base change was introduced in the CpG island in intron 1 of the Igf2 gene splice variant with the most upstream exon 1. LoxP sites were inserted around the CpG island and an FRT flanked neomycin resistance gene cassette was inserted via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:265506)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr143 Mutation: 0 strains or lines available

References

• Original: J:265506 Younis S, et al., The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2048-E2057
• All: 1 reference(s)