Grp^{tm1.1(icre)Himo}
Targeted Allele Detail

Summary

• Symbol: Grp^{tm1.1(icre)Himo}
• Name: gastrin releasing peptide; targeted mutation 1.1, Hisashi Mori
• MGI ID: MGI:6201709
• Synonyms: Grp-iCre
• Gene: Grp Location: Chr18:66005891-66019667 bp, + strand Genetic Position: Chr18, 38.98 cM
• Alliance: Grp^{tm1.1(icre)Himo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264153
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Grp^{tm1.1(icre)Himo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grp (MGI:95833)

• Mutation details: iCre and FRT flanked pgk-neo cassettes were inserted into the gastrin-releasing peptide gene (Grp) locus translation initiation site by homologous recombination in ES cells. The chimeric mouse obtained was crossed with a CAG-FLPe mouse to delete the pgk-neo cassette and establish the mouse line. (J:264153)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grp (mouse) Summary of all recombinase alleles driven by Grp. Comparative matrix view of recombinase activities Alliance mouse Grp gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grp Mutation: 30 strains or lines available

References

• Original: J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7:e34135
• All: 1 reference(s)