Nr3c1^tm1.1Himo
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm1.1Himo
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, Hisashi Mori
• MGI ID: MGI:6201713
• Synonyms: Nr3c1^loxP
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm1.1Himo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264153
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted into mouse Nr3c1 gene to flank exon 3, follwed by a pgk-Neo cassette flanked by two FRT sites by homologous recombination in ES cells. The chimeric mouse obtained was crossed with a CAG-FLPe mouse to delete the pgk-neo cassette and establish the mouse line. (J:264153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 35 strains or lines available

References

• Original: J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7:e34135
• All: 1 reference(s)