Pkd2^tm1.1Gwu
Targeted Allele Detail

Summary

• Symbol: Pkd2^tm1.1Gwu
• Name: polycystin 2, transient receptor potential cation channel; targeted mutation 1.1, Guanqing Wu
• MGI ID: MGI:6201745
• Synonyms: Pkd2^f3
• Gene: Pkd2 Location: Chr5:104607316-104653685 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Pkd2^tm1.1Gwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166881
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette flanked by two FRT sites was inserted upstream of exon 3 and two loxP sites were inserted to flank exon 3. Flp-mediated recombination removed the selection cassette, leaving exon 3 floxed. (J:166881)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd2 Mutation: 85 strains or lines available

References

• Original: J:166881 Kim I, et al., Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin. J Am Soc Nephrol. 2009 Dec;20(12):2556-69
• All: 2 reference(s)