Ntsr2^{tm1.1(cre)Giml}
Targeted Allele Detail

Summary

• Symbol: Ntsr2^{tm1.1(cre)Giml}
• Name: neurotensin receptor 2; targeted mutation 1.1, Gina M Leinninger
• MGI ID: MGI:6202113
• Synonyms: NtsR2^deltaNEO-Cre, NtsR2^Dev
• Gene: Ntsr2 Location: Chr12:16703477-16710223 bp, + strand Genetic Position: Chr12, 7.98 cM
• Alliance: Ntsr2^{tm1.1(cre)Giml} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263745
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ntsr2^{tm1.1(cre)Giml} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntsr2 (MGI:108018)

• Mutation details: The targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR2 gene, with an FRT-flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Mice were bred to a FlpO deleter line to remove neo cessette to make constitutive cre expression throughout life. (J:263745)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntsr2 (mouse) Summary of all recombinase alleles driven by Ntsr2. Comparative matrix view of recombinase activities Alliance mouse Ntsr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntsr2 Mutation: 22 strains or lines available

References

• Original: J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1):ENEURO.0191-17.2018
• All: 2 reference(s)