Vrtn^em#Lhhg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vrtn^em#Lhhg
• Name: vertebrae development associated; endonuclease-mediated mutation, Lusheng Huang
• MGI ID: MGI:6202694
• Gene: Vrtn Location: Chr12:84687793-84698229 bp, + strand Genetic Position: Chr12, 39.32 cM
• Alliance: Vrtn^em#Lhhg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-targeting was used to generate a knock-out allele. Three lines were generated with: a 2 bp deletion (CA; #1), a 10 bp deletion (GGCATGATCG; #34) and another 2 bp deletion (AT; #37). Two unspecified lines were used for analysis and are represented by the pound symbol (#). (J:264400)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vrtn Mutation: 28 strains or lines available

References

• Original: J:264400 Duan Y, et al., VRTN is Required for the Development of Thoracic Vertebrae in Mammals. Int J Biol Sci. 2018;14(6):667-681
• All: 1 reference(s)