Clspn^tm1.1Hmas
Targeted Allele Detail

Summary

• Symbol: Clspn^tm1.1Hmas
• Name: claspin; targeted mutation 1.1, Hisao Masai
• MGI ID: MGI:6203617
• Gene: Clspn Location: Chr4:126450728-126487696 bp, + strand Genetic Position: Chr4, 60.9 cM
• Alliance: Clspn^tm1.1Hmas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240838
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:240838)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clspn Mutation: 55 strains or lines available

References

• Original: J:240838 Yang CC, et al., Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. Nat Commun. 2016 Jul 12;7:12135
• All: 1 reference(s)