Frmd8^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Frmd8^{tm1.1(KOMP)Vlcg}
• Name: FERM domain containing 8; targeted mutation 1.1, Velocigene
• MGI ID: MGI:6203645
• Gene: Frmd8 Location: Chr19:5901002-5925297 bp, - strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Frmd8^{tm1.1(KOMP)Vlcg} page

Mutation origin

• Mutant Cell Line: 17364A-C3
• Germline Transmission: Earliest citation of germline transmission: J:264397
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 22211bp between positions 5852581-5874791 of Chromosome 19 (Genome Build37). Cre-mediated recombination removed the floxed selection and reporter cassette. (J:264397)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frmd8 Mutation: 21 strains or lines available

References

• Original: J:264397 Kunzel U, et al., FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 2018 Jun 13;7:e35012
• All: 1 reference(s)