Slc9a9^tm1.1Yzj
Targeted Allele Detail

Summary

• Symbol: Slc9a9^tm1.1Yzj
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9; targeted mutation 1.1, Yanli Zhang-James
• MGI ID: MGI:6209388
• Gene: Slc9a9 Location: Chr9:94551962-95112498 bp, + strand Genetic Position: Chr9, 49.22 cM
• Alliance: Slc9a9^tm1.1Yzj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265802
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted upstream of the targeted exon. The cassette is composed of an FRT site followed by a splice acceptor site, IRES, a lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, an SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon. The targeted exon is thus flanked by loxP sites. Cre mediated recombination removed the targeted exon creating a reporter knockout allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:265802)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a9 Mutation: 42 strains or lines available

References

• Original: J:265802 Yang L, et al., Autism spectrum disorder traits in Slc9a9 knock-out mice. Am J Med Genet B Neuropsychiatr Genet. 2016 Apr;171B(3):363-76
• All: 1 reference(s)