Spry2^tm1Ssan
Targeted Allele Detail

Summary

• Symbol: Spry2^tm1Ssan
• Name: sprouty RTK signaling antagonist 2; targeted mutation 1, Shomyseh Sanjabi
• MGI ID: MGI:6209492
• Synonyms: Spry2^flx
• Gene: Spry2 Location: Chr14:106129381-106134253 bp, - strand Genetic Position: Chr14, 56.16 cM
• Alliance: Spry2^tm1Ssan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265930
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by a loxP site on one side and a loxP site flanked neomycin resistance gene cassette on the other. This creates a conditional-ready allele with exon 2 (containing the entire coding region) floxed. (J:265930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry2 Mutation: 24 strains or lines available

References

• Original: J:265930 Shehata HM, et al., Lack of Sprouty 1 and 2 enhances survival of effector CD8(+) T cells and yields more protective memory cells. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8939-E8947
• All: 1 reference(s)