Slc9a6^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Slc9a6^tm1Tigm
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 6; targeted mutation 1, Texas A&M Institute of Genomic Medicine
• MGI ID: MGI:6209685
• Synonyms: TG0127
• Gene: Slc9a6 Location: ChrX:55655117-55709590 bp, + strand Genetic Position: ChrX, 30.06 cM
• Alliance: Slc9a6^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/Neo cassette replaced exons 2 and 3. This insertion is predicted to cause an early truncation before the exchanger domain and/or non-sense-mediated mRNA decay. Western blot analysis confirmed loss of protein. (J:262453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a6 Mutation: 10 strains or lines available

References

• Original: J:262453 Xu M, et al., Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome. eNeuro. 2017 Nov-Dec;4(6):ENEURO.0388-17.2017
• All: 1 reference(s)