Wnk4^tm3.1Suc
Targeted Allele Detail

Summary

• Symbol: Wnk4^tm3.1Suc
• Name: WNK lysine deficient protein kinase 4; targeted mutation 3.1, Shinchi Uchida
• MGI ID: MGI:6214838
• Synonyms: WNK4^-
• Gene: Wnk4 Location: Chr11:101151393-101168235 bp, + strand Genetic Position: Chr11, 64.51 cM
• Alliance: Wnk4^tm3.1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241978
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 2. Cre-mediated recombination deleted exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein in kidney. (J:241978)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk4 Mutation: 58 strains or lines available

References

• Original: J:241978 Takahashi D, et al., WNK4 is the major WNK positively regulating NCC in the mouse kidney. Biosci Rep. 2014 May 09;34(3):e00107
• All: 3 reference(s)