Lama2^dy-Pas
Spontaneous Allele Detail

Summary

• Symbol: Lama2^dy-Pas
• Name: laminin, alpha 2; dystrophia muscularis Pasteur
• MGI ID: MGI:6220701
• Synonyms: dy^Pas
• Gene: Lama2 Location: Chr10:26857281-27493021 bp, - strand Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
• Alliance: Lama2^dy-Pas page

Mutation origin

• Strain of Origin: Non-inbred stock

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutations: Insertion, Viral insertion
• Mutation details: This allele contains a 290 bp spontaneous insertion of the long terminal repeat of an intracisternal A-particle gene (IAP) and a 6.1 kb insertion of retrotransposon elements at nucleotide position 5113 (between exons 34 and 35). The translational reading frame is shifted from amino acid position 1706 and a stop codon appeared 12 codons later, producing a putative truncated protein devoid of domain I and II and the C-terminal G domain. (J:102806)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama2 Mutation: 177 strains or lines available

Notes

First observed in 1994 at the animal facility of the Pasteur Institute in Paris (France) in animals derived from a non-inbred agouti background (J:102806).

References

• Original: J:102806 Besse S, et al., Spontaneous muscular dystrophy caused by a retrotransposal insertion in the mouse laminin alpha2 chain gene. Neuromuscul Disord. 2003 Mar;13(3):216-22
• All: 1 reference(s)