Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Daniel H Geschwind |
MGI ID: |
MGI:6220715 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:254962
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Inducible, Knockdown, RMCE-ready) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg involves 1 genes/genome features (Fxn)
View all
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Mutation details: A short hairpin RNA directed against the frataxin gene was targeted into the Rosa26 locus. The shRNA sequence is under the regulation of the tetO operator and a codon optimized tet repressor (itetR) under the control of the CAG promoter. The construct was transfected into LW-4 ES cells through Recombinase Mediated Cassette Exchange
(J:254962)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
992 strains or lines available
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Original: |
J:254962 Chandran V, et al., Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia. Elife. 2017 Dec 19;6:e30054 |
All: |
2 reference(s) |
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