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Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Daniel H Geschwind
MGI ID: MGI:6220715
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:254962
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inducible, Knockdown, RMCE-ready)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
  Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg involves 1 genes/genome features (Fxn) View all
 
Mutation detailsA short hairpin RNA directed against the frataxin gene was targeted into the Rosa26 locus. The shRNA sequence is under the regulation of the tetO operator and a codon optimized tet repressor (itetR) under the control of the CAG promoter. The construct was transfected into LW-4 ES cells through Recombinase Mediated Cassette Exchange (J:254962)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
Notes
LW-4 ES cells = 129SvEv
References
Original:  J:254962 Chandran V, et al., Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia. Elife. 2017 Dec 19;6:e30054
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory