Xcl1^tm1.2Ksho
Targeted Allele Detail

Summary

• Symbol: Xcl1^tm1.2Ksho
• Name: chemokine (C motif) ligand 1; targeted mutation 2.1, Tsuneyasu Kaisho
• MGI ID: MGI:6220923
• Gene: Xcl1 Location: Chr1:164759216-164763094 bp, - strand Genetic Position: Chr1, 72.26 cM
• Alliance: Xcl1^tm1.2Ksho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235786
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the slection cassette and left exons 2 and 3 floxed. Cre-mediated recombination removed exons 2 and 3. (J:235786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xcl1 Mutation: 11 strains or lines available

References

• Original: J:235786 Ohta T, et al., Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 2016 Mar 23;6:23505
• All: 1 reference(s)